MTHFD1L Back

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like

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NCBI Description of MTHFD1L
The protein encoded by this gene is involved in the synthesis of tetrahydrofolate (THF) in the mitochondrion. THF is important in the de novo synthesis of purines and thymidylate and in the regeneration of methionine from homocysteine. Several transcript variants encoding different isoforms have been found for this gene.

Community Annotation of MTHFD1L Add / Edit MTHFD1L: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MTHFD1L is highly significantly mutated in
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MTHFD1L is significantly mutated in
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MTHFD1L is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MTHFD1L