MTERF Back

mitochondrial transcription termination factor

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NCBI Description of MTERF

This gene encodes a mitochondrial transcription termination factor. This protein participates in attenuating transcription from the mitochondrial genome; this attenuation allows higher levels of expression of 16S ribosomal RNA relative to the tRNA gene downstream. The product of this gene has three leucine zipper motifs bracketed by two basic domains that are all required for DNA binding. There is evidence that, for this protein, the zippers participate in intramolecular interactions that establish the three-dimensional structure required for DNA binding.

Community Annotation of MTERF Add / Edit MTERF: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MTERF is highly significantly mutated in
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MTERF is significantly mutated in
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MTERF is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for MTERF