methylthioadenosine phosphorylase

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NCBI Description of MTAP

This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown.

Community Annotation of MTAP Add / Edit MTAP: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


MTAP is highly significantly mutated in
MTAP is significantly mutated in
MTAP is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for MTAP