MSTN Back

myostatin

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NCBI Description of MSTN
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth.

Community Annotation of MSTN Add / Edit MSTN: Annotations

No community annotations yet for MSTN.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MSTN is highly significantly mutated in
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MSTN is significantly mutated in
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MSTN is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MSTN