MST1 Back

macrophage stimulating 1 (hepatocyte growth factor-like)

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NCBI Description of MST1
The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds.

Community Annotation of MST1 Add / Edit MST1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MST1 is highly significantly mutated in
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MST1 is significantly mutated in
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MST1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MST1