MSH2 Back

mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)

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NCBI Description of MSH2
This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of MSH2 Add / Edit MSH2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MSH2 is highly significantly mutated in
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MSH2 is significantly mutated in
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MSH2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MSH2