MRC2 Back

mannose receptor, C type 2

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NCBI Description of MRC2
This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease.

Community Annotation of MRC2 Add / Edit MRC2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MRC2 is highly significantly mutated in
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MRC2 is significantly mutated in
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MRC2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MRC2