MRAP Back

melanocortin 2 receptor accessory protein

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NCBI Description of MRAP
This gene encodes a melanocortin receptor-interacting protein. The encoded protein regulates trafficking and function of the melanocortin 2 receptor in the adrenal gland. The encoded protein can also modulate signaling of other melanocortin receptors. Mutations in this gene have been associated with familial glucocorticoid deficiency type 2. Alternatively spliced transcript variants have been described.

Community Annotation of MRAP Add / Edit MRAP: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MRAP is highly significantly mutated in
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MRAP is significantly mutated in
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MRAP is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MRAP