MPP4 Back

membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)

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NCBI Description of MPP4

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) protein family, with an N-terminal PDZ domain, a central src homology 3 region (SH3), and a C-terminal guanylate kinase-like (GUK) domain. The protein is localized to the outer limiting membrane in the retina, and is thought to function in photoreceptor polarity and the organization of specialized intercellular junctions. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Community Annotation of MPP4 Add / Edit MPP4: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MPP4 is highly significantly mutated in
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MPP4 is significantly mutated in
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MPP4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for MPP4