MPP3 Back

membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)

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NCBI Description of MPP3

This gene product is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. This protein contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. Alternatively spliced transcript variants have been identified. One transcript variant is experimentally supported, but it doesn't encode a protein.

Community Annotation of MPP3 Add / Edit MPP3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MPP3 is highly significantly mutated in
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MPP3 is significantly mutated in
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MPP3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for MPP3