MPO Back

myeloperoxidase

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NCBI Description of MPO
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils.

Community Annotation of MPO Add / Edit MPO: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MPO is highly significantly mutated in
MPO is significantly mutated in
Kidney clear cell
KIRC
4 patients (0%)
MPO is near significance in

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MPO