MOGS Back

mannosyl-oligosaccharide glucosidase

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NCBI Description of MOGS

This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of MOGS Add / Edit MOGS: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MOGS is highly significantly mutated in
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MOGS is significantly mutated in
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MOGS is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for MOGS