MMP24 Back

matrix metallopeptidase 24 (membrane-inserted)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of MMP24
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24.

Community Annotation of MMP24 Add / Edit MMP24: Annotations

No community annotations yet for MMP24.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MMP24 is highly significantly mutated in
(none)
MMP24 is significantly mutated in
(none)
MMP24 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MMP24