MMP19 Back

matrix metallopeptidase 19

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NCBI Description of MMP19
This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene.

Community Annotation of MMP19 Add / Edit MMP19: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MMP19 is highly significantly mutated in
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MMP19 is significantly mutated in
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MMP19 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MMP19