MMP16 Back

matrix metallopeptidase 16 (membrane-inserted)

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NCBI Description of MMP16
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16.

Community Annotation of MMP16 Add / Edit MMP16: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MMP16 is highly significantly mutated in
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MMP16 is significantly mutated in
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MMP16 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MMP16