MKRN2 Back

makorin, ring finger protein, 2

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NCBI Description of MKRN2
This gene encodes a probable E3 ubiquitin ligase containing several zinc finger domains, that is a member of the makorin RING zinc-finger protein family. This gene overlaps the v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1) gene in an antisense orientation and may have a co-regulatory function with RAF1. Alternative splicing results in multiple transcript variants.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MKRN2 is highly significantly mutated in
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MKRN2 is significantly mutated in
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MKRN2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MKRN2