MKNK1 Back

MAP kinase interacting serine/threonine kinase 1

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NCBI Description of MKNK1

This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene.

Community Annotation of MKNK1 Add / Edit MKNK1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MKNK1 is highly significantly mutated in
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MKNK1 is significantly mutated in
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MKNK1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for MKNK1