MKL1 Back

megakaryoblastic leukemia (translocation) 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of MKL1
The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia.

Community Annotation of MKL1 Add / Edit MKL1: Annotations

No community annotations yet for MKL1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MKL1 is highly significantly mutated in
(none)
MKL1 is significantly mutated in
(none)
MKL1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MKL1