MKL1 Back

megakaryoblastic leukemia (translocation) 1

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NCBI Description of MKL1

The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


MKL1 is highly significantly mutated in
MKL1 is significantly mutated in
MKL1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for MKL1