MIF Back

macrophage migration inhibitory factor (glycosylation-inhibiting factor)

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NCBI Description of MIF
This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways.

Community Annotation of MIF Add / Edit MIF: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MIF is highly significantly mutated in
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MIF is significantly mutated in
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MIF is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MIF