MICB Back

MHC class I polypeptide-related sequence B

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NCBI Description of MICB
This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides.

Community Annotation of MICB Add / Edit MICB: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MICB is highly significantly mutated in
(none)
MICB is significantly mutated in
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MICB is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MICB