MICA Back

MHC class I polypeptide-related sequence A

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NCBI Description of MICA
MICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Alternative splicing results in multiple transcript variants.

Community Annotation of MICA Add / Edit MICA: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MICA is highly significantly mutated in
(none)
MICA is significantly mutated in
(none)
MICA is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MICA