malignant fibrous histiocytoma amplified sequence 1

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NCBI Description of MFHAS1

Identified in a human 8p amplicon, this gene is a potential oncogene whose expression is enhanced in some malignant fibrous histiocytomas (MFH). The primary structure of its product includes an ATP/GTP-binding site, three leucine zipper domains, and a leucine-rich tandem repeat, which are structural or functional elements for interactions among proteins related to the cell cycle, and which suggest that overexpression might be oncogenic with respect to MFH.

Community Annotation of MFHAS1 Add / Edit MFHAS1: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


MFHAS1 is highly significantly mutated in
MFHAS1 is significantly mutated in
MFHAS1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for MFHAS1