NCBI Description of METAP2
|This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2.|
Community Annotation of METAP2 Add / Edit METAP2: Annotations
No community annotations yet for METAP2.
• "Mouse over" a mutation to see details.
Click on a tumor type to see its full list of significant genes.