MERTK Back

c-mer proto-oncogene tyrosine kinase

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NCBI Description of MERTK
This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).

Community Annotation of MERTK Add / Edit MERTK: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MERTK is highly significantly mutated in
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MERTK is significantly mutated in
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MERTK is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MERTK