MEGF8 Back

multiple EGF-like-domains 8

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NCBI Description of MEGF8

The protein encoded by this gene is a single-pass type I membrane protein of unknown function that contains several EGF-like domains, Kelch repeats, and PSI domains. Defects in this gene are a cause of Carpenter syndrome 2. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of MEGF8 Add / Edit MEGF8: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


MEGF8 is highly significantly mutated in
MEGF8 is significantly mutated in
MEGF8 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for MEGF8