MEGF10 Back

multiple EGF-like-domains 10

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NCBI Description of MEGF10
This gene encodes a member of the multiple epidermal growth factor-like domains protein family. The encoded protein plays a role in cell adhesion, motility and proliferation, and is a critical mediator of apoptotic cell phagocytosis as well as amyloid-beta peptide uptake in the brain. Expression of this gene may be associated with schizophrenia, and mutations in this gene are a cause of early-onset myopathy, areflexia, respiratory distress, and dysphagia (EMARDD) as well as congenital myopathy with minicores. Alternatively spliced transcript variants have been observed for this gene.

Community Annotation of MEGF10 Add / Edit MEGF10: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MEGF10 is highly significantly mutated in
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MEGF10 is significantly mutated in
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MEGF10 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MEGF10