MED7 Back

mediator complex subunit 7

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of MED7
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Two transcript variants encoding the same protein have been found for this gene.

Community Annotation of MED7 Add / Edit MED7: Annotations

No community annotations yet for MED7.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MED7 is highly significantly mutated in
(none)
MED7 is significantly mutated in
(none)
MED7 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MED7