ME3 Back

malic enzyme 3, NADP(+)-dependent, mitochondrial

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ME3
Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.

Community Annotation of ME3 Add / Edit ME3: Annotations

No community annotations yet for ME3.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ME3 is highly significantly mutated in
(none)
ME3 is significantly mutated in
(none)
ME3 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ME3