MDK Back

midkine (neurite growth-promoting factor 2)

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NCBI Description of MDK

This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed.

Community Annotation of MDK Add / Edit MDK: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


MDK is highly significantly mutated in
MDK is significantly mutated in
MDK is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for MDK