MDH2 Back

malate dehydrogenase 2, NAD (mitochondrial)

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NCBI Description of MDH2

Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


MDH2 is highly significantly mutated in
MDH2 is significantly mutated in
MDH2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for MDH2