MDH1 Back

malate dehydrogenase 1, NAD (soluble)

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NCBI Description of MDH1
Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the cytoplasm and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Community Annotation of MDH1 Add / Edit MDH1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MDH1 is highly significantly mutated in
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MDH1 is significantly mutated in
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MDH1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MDH1