MCL1 Back

myeloid cell leukemia sequence 1 (BCL2-related)

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NCBI Description of MCL1
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.

Community Annotation of MCL1 Add / Edit MCL1: Annotations

No community annotations yet for MCL1.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MCL1 is highly significantly mutated in
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MCL1 is significantly mutated in
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MCL1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MCL1