MCF2 Back

MCF.2 cell line derived transforming sequence

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NCBI Description of MCF2
The oncogenic protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that exerts control over some members of the Rho family of small GTPases. Several transcript variants encoding different isoforms have been found for this gene. These isoforms exhibit different expression patterns and varying levels of GEF activity.

Community Annotation of MCF2 Add / Edit MCF2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MCF2 is highly significantly mutated in
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MCF2 is significantly mutated in
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MCF2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MCF2