MCC Back

mutated in colorectal cancers

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of MCC

This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of MCC Add / Edit MCC: Annotations

No community annotations yet for MCC.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MCC is highly significantly mutated in
(none)
MCC is significantly mutated in
(none)
MCC is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for MCC