MBL2 Back

mannose-binding lectin (protein C) 2, soluble (opsonic defect)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of MBL2
This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.

Community Annotation of MBL2 Add / Edit MBL2: Annotations

No community annotations yet for MBL2.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MBL2 is highly significantly mutated in
(none)
MBL2 is significantly mutated in
(none)
MBL2 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MBL2