MASP2 Back

mannan-binding lectin serine peptidase 2

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NCBI Description of MASP2
The Ra-reactive factor (RARF) is a complement-dependent bactericidal factor that binds to the Ra and R2 polysaccharides expressed by certain enterobacteria. Alternate splicing of this gene results in two transcript variants encoding two RARF components that are involved in the mannan-binding lectin pathway of complement activation. The longer isoform is cleaved into two chains which form a heterodimer linked by a disulfide bond. The encoded proteins are members of the trypsin family of peptidases.

Community Annotation of MASP2 Add / Edit MASP2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MASP2 is highly significantly mutated in
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MASP2 is significantly mutated in
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MASP2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MASP2