MARK2 Back

MAP/microtubule affinity-regulating kinase 2

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NCBI Description of MARK2

This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


MARK2 is highly significantly mutated in
MARK2 is significantly mutated in
MARK2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for MARK2