MARCKS Back

myristoylated alanine-rich protein kinase C substrate

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NCBI Description of MARCKS
The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MARCKS is highly significantly mutated in
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MARCKS is significantly mutated in
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MARCKS is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MARCKS