MARCH6 Back

membrane-associated ring finger (C3HC4) 6

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NCBI Description of MARCH6
This gene encodes a member of a family of membrane-associated E3 ubiquitin ligases containing RING-CH-type zinc finger motifs. Ubiquitination of type II deiodinase by the encoded protein is an important regulatory step in thyroid hormone signalling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Community Annotation of MARCH6 Add / Edit MARCH6: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MARCH6 is highly significantly mutated in
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MARCH6 is significantly mutated in
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MARCH6 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MARCH6