membrane-associated ring finger (C3HC4) 5

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of MARCH5

MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2; MIM 608507) and DRP1 (DNM1L; MIM 603850) (Nakamura et al., 2006 [PubMed 16936636]).[supplied by OMIM, Mar 2008].

Community Annotation of MARCH5 Add / Edit MARCH5: Annotations

No community annotations yet for MARCH5.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


MARCH5 is highly significantly mutated in
MARCH5 is significantly mutated in
MARCH5 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for MARCH5