MARCH5 Back

membrane-associated ring finger (C3HC4) 5

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NCBI Description of MARCH5
MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2; MIM 608507) and DRP1 (DNM1L; MIM 603850) (Nakamura et al., 2006 [PubMed 16936636]).[supplied by OMIM, Mar 2008].

Community Annotation of MARCH5 Add / Edit MARCH5: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MARCH5 is highly significantly mutated in
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MARCH5 is significantly mutated in
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MARCH5 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MARCH5