MARCH4 Back

membrane-associated ring finger (C3HC4) 4

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NCBI Description of MARCH4
MARCH4 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH4 reduces surface accumulation of several membrane glycoproteins by directing them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010].

Community Annotation of MARCH4 Add / Edit MARCH4: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MARCH4 is highly significantly mutated in
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MARCH4 is significantly mutated in
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MARCH4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MARCH4