MARCH11 Back

membrane-associated ring finger (C3HC4) 11

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NCBI Description of MARCH11
MARCH11 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). These enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their intracellular transport. March11 appears to have a role in ubiquitin-mediated protein sorting in the trans-Golgi network (TGN)-multivesicular body (MVB) transport pathway (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010].

Community Annotation of MARCH11 Add / Edit MARCH11: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MARCH11 is highly significantly mutated in
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MARCH11 is significantly mutated in
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MARCH11 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MARCH11