MAPKAPK2 Back

mitogen-activated protein kinase-activated protein kinase 2

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NCBI Description of MAPKAPK2
This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MAPKAPK2 is highly significantly mutated in
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MAPKAPK2 is significantly mutated in
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MAPKAPK2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MAPKAPK2