MAPK8IP2 Back

mitogen-activated protein kinase 8 interacting protein 2

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NCBI Description of MAPK8IP2

The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MAPK8IP2 is highly significantly mutated in
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MAPK8IP2 is significantly mutated in
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MAPK8IP2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for MAPK8IP2