MAPK8IP1 Back

mitogen-activated protein kinase 8 interacting protein 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of MAPK8IP1
This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.

Community Annotation of MAPK8IP1 Add / Edit MAPK8IP1: Annotations

No community annotations yet for MAPK8IP1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MAPK8IP1 is highly significantly mutated in
(none)
MAPK8IP1 is significantly mutated in
(none)
MAPK8IP1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MAPK8IP1