MAP4K2 Back

mitogen-activated protein kinase kinase kinase kinase 2

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NCBI Description of MAP4K2
The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MAP4K2 is highly significantly mutated in
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MAP4K2 is significantly mutated in
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MAP4K2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MAP4K2