MAP4 Back

microtubule-associated protein 4

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of MAP4
The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of MAP4 Add / Edit MAP4: Annotations

No community annotations yet for MAP4.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MAP4 is highly significantly mutated in
(none)
MAP4 is significantly mutated in
(none)
MAP4 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MAP4