MAP3K8 Back

mitogen-activated protein kinase kinase kinase 8

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of MAP3K8

This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein.

Community Annotation of MAP3K8 Add / Edit MAP3K8: Annotations

No community annotations yet for MAP3K8.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MAP3K8 is highly significantly mutated in
(none)
MAP3K8 is significantly mutated in
(none)
MAP3K8 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for MAP3K8