MAP3K6 Back

mitogen-activated protein kinase kinase kinase 6

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NCBI Description of MAP3K6

This gene encodes a member of the serine/threonine protein kinase family. The encoded kinase was identified by its interaction with MAP3K5/ASK, a protein kinase and an activator of c-Jun kinase (MAPK7/JNK) and MAPK14/p38 kinase. This kinase was found to weakly activate MAPK7, but not MAPK1/ERK or MAPK14. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MAP3K6 is highly significantly mutated in
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MAP3K6 is significantly mutated in
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MAP3K6 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for MAP3K6