MAP3K15 Back

mitogen-activated protein kinase kinase kinase 15

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of MAP3K15
The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates a specific MAPK. This MAP3K protein plays an essential role in apoptotic cell death triggered by cellular stresses. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments, including the related human protein NP_005914.1, but the complete splice pattern has not been experimentally verified.

Community Annotation of MAP3K15 Add / Edit MAP3K15: Annotations

No community annotations yet for MAP3K15.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MAP3K15 is highly significantly mutated in
(none)
MAP3K15 is significantly mutated in
(none)
MAP3K15 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MAP3K15